Impact of Resveratrol on Oxidative and Inflammatory Stress

Resveratrol, the plant extract and potent anti-inflammatory previously shown to extend the survival of lower animal life, seems to reduce inflammation in humans as well due to a reduction in blood vessel inflammation.

Many remember resveratrol as a supplement used to fight aging. Thus far, however, the only scientific studies to demonstrate this benefit have occurred using yeast, worms, fruit flies, fish, and mice. P aresh Dandona,MD,PHD,in a new study that was conducted in the university of buffalo,noted that no data exist on the impact of resveratrol on oxidative and inflammatory stress in people. So the researchers decided to determine if the compound reduces the level of oxidative and inflammatory stress in humans.This study was also the first of its kind at the university The study involved 20 randomized volunteers. 10 people received 40 mg resveratrol once daily for six weeks, and 10 received placebo.

Researchers collected fasting blood samples at baseline and at weeks 1, 3, and 6. The blood samples of those who took resveratrol showed that the pythonutrient suppressed the generatio of free radicals which caused oxidative stress and release factors that promote inflammation.The blood samples also revealed suppression of other compounds that interfere with insulin action, resulting in an increased risk of developing diabetes. In addition to studies on resveratrol and aging, other research has suggested the phytonutrient may provide other benefits.

One study, for example, found that resveratrol improved symptoms of inflammatory bowel disease, while another indicated it may help prevent blindness The results of this study,while promising,did not eliminate the possibility that another element in the extract,besides resveratrol,was responsible for reducing inflammation, since the scientists used a product that was only 20 percent resveratrol.However,Dandona noted they intend to conduct further studies using purer formulations of resveratrol. More study information can be found here.

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